Travoprost(13)was obtained with benzoyl Corey lactone(1)as the starting material in a ten-step synthetic route,which consisted of selective oxidation in the presence of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)/sodium hypochlorite,Wittig-Hornor reaction,chiral reduction,debenzoylation,triethylchlorosilane protection of hydroxyl,lactone reduction,Wittig reaction,ester formation,hydroxyl protection and deprotection,with the total yield of 15.3％.The structure of the final product was confirmed by 1H NMR,13C NMR and MS.In this paper,the separation and purification processes of various intermediates were simplified by pulping with ethanol/n-hexane,recrystallization by methyl tert-butyl ether and separation by silica gel column chromatography.By the way,the synthetic route had the advantages of availability of raw materials,and mild and controllable reaction conditions,which could provide some references for the industrial production of travoprost generic drugs.
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