Preparation and Preliminary Quality Evaluation of Cream Loaded with Wintergreen Oil Cyclodextrin Inclusion Complexes
Wintergreen oil inclusion complexes with α-,β-,or γ-cyclodextrin(CD)were respectively prepared by the saturated aqueous solution method,then their corresponding creams were also prepared.The in vitro transdermal permeation and release behaviors of aforementioned inclusion complex-based creams were investigated by the modified Franz diffusion cell method.The results showed that among the three inclusion complexes of wintergreen oil,the γ-CD inclusion complexes had the highest inclusion rate and yield,which were(88.53±0.72)％and(98.21±0.80)％respectively.And the cream loaded with the γ-CD inclusion complexes also had the highest in vitro transdermal permeation and release rates among the three creams;its in vitro release data were fitted to zero order kinetic model.Compared with the commercially available compound methyl salicylate cream,three creams loaded with different inclusion complexes had lower in vitro transdermal permeation and release rates,but had no obvious skin irritation.It was concluded that the cream loaded with the γ-CD inclusion complexes had good appearance and stability,no skin irritation,and showed a certain therapeutic effect on chronic eczema model rats.
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