The dissolution of cetylpyridinium chloride(1)buccal tablets was determined by flow-through cell method,and the concentration of the dissolution medium,the construction method and amount of glass beads,and the flow rate of the flow-through cell were optimized.Meanwhile,the dissolution curves of the self-made and reference samples were tested using the established method.The results showed that the concentration of the dissolution medium and the amount of glass beads had little effect on the release behavior,while different glass bead construction methods and flow rates of the flow-through cell had a significant effect on the release behavior.This method has certain feasibility and discriminatory ability,which can be used to evaluate the in vitro dissolution behavior of 1 buccal tablets.
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