摘要
微针是一种无痛的透皮给药系统,因可避免首过效应、血药浓度平稳、生物利用度高、安全性好,以及患者依从性良好等优势,成为近年来药物制剂开发的热点,但仍存在生物相容性差、载药量小、药物释放不稳定,以及受限于针体机械性能等问题.微针材料对微针临床应用方向、载药能力和药物稳定性影响巨大.该综述归纳和整理了各类新型微针材料的研究进展以及应用方向和前景,以期为微针制剂开发提供参考.
Abstract
Microneedle is a painless transdermal drug delivery system that has become a hot topic in drug formulation development in recent years due to its numerous advantages of avoiding the first-pass effect,maintaining smooth blood concentration,and providing high bioavailability,good safety and patient compliance.However,despite these benefits,there are several challenges associated with microneedle technology,including poor biocompatibility,limited drug loading capacity,unstable drug release,and restricted mechanical properties.The microneedle materials play a crucial role in determining the direction of clinical applications,drug-loading capability,and drug stability.This review summarizes and organizes the research progress made in the field of various new microneedle materials,as well as highlights their potential applications and prospects,hoping to provide a valuable reference for the development of microneedle formulations.
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