Eight related substances of ceritinib(1)were prepared according to its structure and synthetic process,namely 5-chloro-2-isopropoxy-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine(related substance A),5-chloro-4-[[2-(isopropylsulfonyl)phenyl]amino]pyrimidin-2-ol(related substance B),5-chloro-N2-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N4-[2-(isopropylsulfinyl)phenyl]pyrimidine-2,4-diamine(related substance C),5-chloro-N2-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N4-[2-(propylsulfonyl)phenyl]pyrimidine-2,4-diamine(related substance D),5-chloro-N4-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N2-[2-(isopropylsulfonyl)phenyl]-pyrimidine-2,4-diamine(related substance E),2-[[5-chloro-4-[[2-(isopropylsulfonyl)phenyl]amino]pyrimidin-2-yl]amino]-4-methyl-5-(piperidin-4-yl)phenol(related substance F),4-[4-[4-[[5-chloro-4-[[2-(isopropylsulfonyl)-phenyl]amino]pyrimidin-2-yl]amino]-5-isopropoxy-2-methylphenyl]piperidin-1-yl]pentan-2-one(related substance G),5-chloro-N2-[4-[1-[5-chloro-4-[[2-(isopropylsulfonyl)phenyl]amino]pyrimidin-2-yl]piperidin-4-yl]-2-isopropoxy-5-methylphenyl]-N4-[2-(isopropylsulfonyl)phenyl]pyrimidine-2,4-diamine(related substance H).And their structures were confirmed by 1H NMR and MS.
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