3D打印技术在膜剂制备中的研究进展
Research Progress of 3D Printing Technology in Manufacture of Pharmaceutical Films
张隽齐 1杨柳榴 1陈芳1
作者信息
- 1. 中国医药工业研究总院医药先进制造国家工程研究中心,上海 201203
- 折叠
摘要
膜剂具有患者依从性好、携带及服药方便、剂量准确等特点.3D打印技术是基于计算机辅助设计模型的增材制造技术,一般通过分层打印、逐层叠加的方式构建物体,具有可提供复杂结构、制备复方制剂及个性化药物等优势.文章介绍了在膜剂制备中应用较广泛的喷墨打印、熔融沉积成型和半固体挤出技术,简要概述了 3D打印膜剂的处方组成及关键工艺参数,以期为3D打印技术在膜剂领域的进一步应用和研究提供参考.
Abstract
The pharmaceutical films have the characteristics of good patient compliance,convenience for carrying and taking,and accurate dosage.3D printing technology is an additive manufacturing technology based on computer-aided design models,which generally builds objects by layer-by-layer printing and stacking.It has the advantages of providing complex structures,developing compound preparations and personalized medicines.This review gives an overview of the widely used 3D printing technologies in the preparation of pharmaceutical films,including inkjet printing,fused deposition molding,and semi-solid extrusion.Then,the formulation composition and key process parameters of 3D printing technologies are briefly outlined.It is hoped that this review can provide some references for further researches on the application of 3D printing technology in the field of pharmaceutical films.
关键词
3D打印/膜剂/复方制剂/个性化药物/计算机辅助设计Key words
3D printing/pharmaceutical film/compounded preparation/personalized medicine/computer-aided design引用本文复制引用
出版年
2024
NETL
NSTL
万方数据