Preliminary Verification and Application of Flow-through Cell Apparatus for Pharmaceutical Films
In this study,a flow-through cell based apparatus was developed to explore the method of dissolution determination for pharmaceutical films.The results of accuracy tests on sampling and temperature controlling showed that the apparatus performed well on accuracy control under different flow rate conditions of 1,2 and 5 mL/min.Granisetron hydrochloride orodispersible film,asenapine maleate sublingual film,rasagiline mesylate sublingual film and tadalafil orodispersible film were selected as model drugs to verify the fixed method of film,fluid morphology,and tightness of the dissolution cell,and corresponding improvements were proposed.The results indicated that through dispersing the dissolution media with a filter core,fixing the film with a screen mesh,and enhancing the tightness of dissolution cell,this apparatus could achieve primary functions on dissolution with the potential of application universality for different pharmaceutical films and flow rates.
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