The rapid development of inhaled products,especially dry powder for inhalation,highlights the quantitative demands for the amorphous content of micronized bulk drugs.This review briefly describes seven widely used quantitative methods,named PXRD,DSC,dynamic vapor adsorption,microcalorimetry,solution calorimetry,IR and Raman spectroscopy methods,as well as their limitations and corresponding detection instruments.And based on the common limit requirements of amorphous content for inhaled bulk drugs,some examples are provided.The advantages and disadvantages of different methods are analyzed to provide some references for related researches.
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