双层片剂的研究进展
Research Progress on Double-layer Tablets
王楠 1时晓燕 2潘增玉 2贾俊伟 2冯中3
作者信息
- 1. 山东中医药大学药学院,山东济南 250355
- 2. 鲁南制药集团股份有限公司,山东省药物国际化工程实验室,山东临沂 273400
- 3. 山东中医药大学药学院,山东济南 250355;鲁南制药集团股份有限公司,山东省药物国际化工程实验室,山东临沂 273400
- 折叠
摘要
双层片剂是一种广受关注的新型制剂,具有双层结构,可通过联合用药或调整释药速率来增强药效、减轻药物不良反应、提高患者依从性.该综述总结了近年来双层片剂的研究进展,汇总了双层片剂的特点、制备方法和分类情况,并结合案例介绍了双层片剂的临床应用情况,以期为双层片剂的研究与开发提供参考.
Abstract
Double-layer tablets are a novel dosage form which attract wide attention.With bilayer structures,double-layer tablets can enhance drug efficacy,reduce adverse drug reactions and improve patient compliance by combination medication or adjusting the release rate.This review summarizes the research progress of double-layer tablets in recent years,generalizes the characteristics,preparation methods and classification of double-layer tablets,and introduces its clinical applications with case studies.It is hoped to provide a reference for the research and development of double-layer tablets.
关键词
双层片/速释层/缓释层/药效/固体制剂Key words
double-layer tablet/immediate-release layer/sustained-release layer/efficacy/solid dosage form引用本文复制引用
基金项目
山东省泰山产业领军人才项目(TSCX202306086)
山东省重大科技创新工程项目(2020CXGC010506)
出版年
2024
NETL
NSTL
万方数据