Preparation of Quercetin Nanocrystals by Microfluidic Technology and Their Pharmacokinetics in Rats
In an effort to enhance the solubility and oral absorption of quercetin(1),this study employed microfluidic technology to formulate quercetin nanocrystals(QNCs).The research investigated the influences of 1 solution flow rate,anti-solvent phase flow rate,and 1 concentration on the particle size of QNCs.The QNCs were then characterized by a variety of techniques including TEM,DSC,and PXRD.The findings revealed that the particle size of the QNCs could be effectively managed by adjusting the solution flow rate and 1 concentration through microfluidic technology.The formulated QNCs exhibited an amorphous form with a particle size of(79.23±0.45)nm and a polydispersity index(PDI)of(0.144±0.008).Then,an in vitro dissolution test in pH 7.4 PBS was carried out.In addition,a comparative pharmacokinetic study was conducted in rats,in which either QNCs or bulk quercetin were administered orally.Moreover,the QNCs demonstrated an improved dissolution rate in vitro and superior oral bioavailability compared to the bulk drug.These results suggest that microfluidic technology offers significant potential for improving the bioavailability of drugs with poor solubility.
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