The Application Development of Organoids for Drug Evaluation
In recent years,organoids and organ chips have been developed rapidly.Organoids show certain advantages such as physiological,human origin,genetic stability,high throughput and easy operation,and can be widely used in many fields including drug development,drug evaluation and regenerative medicine.The application of organoids to drug developing include the evaluation of pharmacodynamics,pharmacokinetics,effectiveness and safety,especially for non-clinical pharmacodynamic evaluation.Here,the applications of organoids and their representative models in drug evaluation are introduced,the regulatory international regulatory policy and industry developments are briefly reviewed.Finally,the applications and challenges of organoids and organ chips for non-clinical alternative or complementary models are discussed.
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