Research and Application of Microbubble Ultrasound Contrast Agents
Ultrasound imaging has been widely used in various fields due to its non-invasiveness,relative simplicity,and no ionizing radiation.Ultrasound contrast agents play an important role in ultrasound imaging,which are usually composed of soft or hard shell materials,with sizes ranging from nanometers to micrometers.And their functions have evolved from initial imaging diagnosis to the integrated mode of diagnosis and treatment.Some marketed ultrasound contrast agents,such as Levovist®,Optison®,Definity® and Sono Vue® have been used in clinical ultrasound examinations in Europe,Asia and elsewhere.This review focuses on the research progress of microbubble ultrasound contrast agents and their clinical applications,in order to provide a reference for the development of new ultrasound contrast agents.