Screening and Activity Study of Humanized CD73 Antibody
Anti-CD73 antibody can inhibit tumor development and metastasis,but there are few studies on its targets and efficacy,and there is no antibody drug on the market at present.In this study,a murine CD73 antibody was humanized,and its efficacy in a mouse solid tumor model was further studied.The results showed that the humanized anti-CD73 20huM51 antibody had a high affinity and neutralizing activity.The anti-CD73 antibody reversed the AMP-mediated inhibition on the release of IFN-y by CD4+T/CD8+T cells and promoted the secretion of IFN-y.At a dose of 20 mg/kg,the antibody had a significant antitumor activity in mice.The tumor volume and weight inhibition rates were 26.3％and 21.6％,respectively.This study provided data support for the preclinical development of anti-CD73 drugs.
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