Analyses of Material Basis and Components Migrating to Blood of Heiguteng Zhuifeng Huoluo Capsules by UPLC-Q-TOF-MS/MS
The material basis and blood-entering components of the Heiguteng Zhuifeng Huoluo Capsules(HZHC)extract were investigated by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry(UPLC-Q-TOF-MS/MS).Based on the retention times,quasi-molecular ion peaks,and secondary mass spectrometry information,combined with the reference substances and literature data,a total of 82 compounds were identified from the HZHC,including 47 alkaloids,9 phenylpropanoids,7 steroids,and 19 other compounds.Based on this,9 prototype compounds absorbed into the blood were identified in the serum of rats that received HZHC via gavage,including 7 alkaloids,which were N-demethylsinomenine,dihydrosinomenine,sinomenine,stepharine,magnoflorine,isosinomenine and 6-O-demethylmenisporphine,1 nucleoside and 1 fatty acid.This preliminary investigation elucidated the material basis and blood-absorbed components of the HZHC,which would provide a reference for subsequent experimental research.
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