Characterization of Dissolution Profiles for Aspirin Enteric Coated Tablets by Reciprocating Cylinder Apparatus
Investigating the impacts of reciprocating frequency and screen aperture on the dissolution behavior of aspirin enteric-coated tablets.Establishing a reciprocating cylinder method for determining the dissolution of aspirin enteric coated tablets,to figure out the in vitro dissolution profiles for.different formulations.The dissolution behavior of reference listed drugs and 4 test formulations was evaluated by f2-bootstrap method,the similarity factor(f2)of the dissolution profiles between formulations A,B,C,D and reference listed drugs was 81.4,33.5,20.9 and 17.9.The dissolution profiles of formulation A and reference listed drugs were similar,however,the dissolution profiles of formulation B,C and D were different.Compared with basket apparatus,using reciprocating cylinder is a discriminative and durable method for dissolution behavior characterization of aspirin enteric-coated tablets,providing reference for the application of reciprocating cylinder method in drug quality evaluation.
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