Formulation,Process and Quality Control Strategies for Amorphous Solid Dispersion-based Preparations
Amorphous solid dispersion is one of the most effective formulation approaches to enhance the oral bioavailability of poorly water-soluble drugs with wide application prospects.However,due to the"aging",a solid state physical stability problem,which affects the dissolution in vitro and absorption in vivo,the development of amorphous solid dispersion-based preparations faces great challenges.The solid state physical stability is affected by many factors such as formulation composition,preparation process and storage conditions.In this paper,formulation composition,preparation process and quality control of amorphous solid dispersion-based preparations are summarized in order to provide the guidance for the development of amorphous solid dispersion-based preparations.
amorphous solid dispersionformulationpreparation processphysical stabilityquality control
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