Proteolysis targeting chimeras(PROTACs)are currently one of the hot spots in antineoplastic agent research.They have efficient and durable anti-tumor effects,good selectivity,and low possible toxicity.This review summarizes the research progress of new PROTAC drugs targeting estrogen receptors,androgen receptors,BCR-ABL,histone deacetylase 4,methyltransferase-like 3.
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