Research Progress of Artificial Intelligence-assisted Development in Oral Formulations
Oral administration is by far the most commonly used route of drug administration.Through the rational design and optimization of oral formulations and their preparation processes,increase of solubility,sustained-and controlled-release of drugs can be achieved,resulting in improved oral bioavailability,enhanced efficacy,reduced toxicity or personalized drug delivery.However,the current formulation and preparation process optimization of oral formulations is still highly dependent on traditional trial-and-error experiments and empirical data,which is time-consuming,laborious,costly,and hardly predictable.Artificial intelligence(AI)technology,which has flourished in recent years,is expected to enable efficient and systematic design of oral formulations.Based on the existing experimental data for oral preparations,a prediction model can be established through AI to predict the relevant indicators of oral preparations and optimize the process parameters of oral preparations.This review summarizes the basic principles and applications of AI-assisted development in oral formulations,discusses and offers prospects on the applications of AI in the field of oral formulations,and provides a reference for accelerating further research and development of pharmaceutical preparations with AI technology.
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