Synthesis of the Related Substances of Fenofibrate
In order to control the quality of fenofibrate,seven related substances of fenofibrate were prepared,namely 4-chloro-4'-hydroxybenzophenone(related substance A),2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid(related substance B),methyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate(related substance C),ethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate(related substance D),2-[[2-(4-(4-chlorobenzoyl)-phenoxy)-2-methylpropanoyl]oxy]-2-methylpropanoic acid(related substance E),2-[4-(4-hydroxybenzoyl)phenoxy]-2-methylpropanoic acid(related substance F),2,2'-[[carbonylbis(4,1-phenylene)]bis(oxy)]bis(2-methylpropanoic acid)(related substance G).Their structures were confirmed by MS and NMR.
fenofibratehypolipidemic drugrelated substancesynthesisquality control
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