The aim of this study was to promote the oral absorption of quercetin(1),an insoluble natural component,using choline-based ionic liquids(ILs).Firstly,a series of ILs composed of choline hydroxide(Ch)and various acids[phenylalanine(Phe),geranic acid(Ger),malonic acid(Mal),sorbic acid(Sorb),succinic acid(Suc)and malic acid(Mala)]were synthesized and characterized extensively.According to the solubility of 1 in various ILs,the ILs with the superior solubilization effects on 1 were screened out,which were choline geranate([Ch][Ger])and choline sorbate([Ch][Sorb]).Then,the in vitro dissolution characteristics and in vivo pharmacokinetic behaviors in SD rats of the above two systems(1-[Ch][Ger]and 1-[Ch][Sorb])were investigated.The results showed that both 1-[Ch][Ger]and 1-[Ch][Sorb]significantly improved the in vitro dissolution rate of 1,but the dissolution rate of the latter at 20 min was similar to that of 1 bulk drug.With 1 suspension as the control,the relative bioavailabilities of 1-[Ch][Ger]and 1-[Ch][Sorb]were 588.0％and 501.9％,respectively.This study is of instructive significance for the investigation of oral preparations of insoluble natural ingredients.
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