Preparation and Pharmacokinetic Study of the Lipid-coated Curcumin Nanoparticles
A drug delivery system of lipid-coated hollow mesoporous silica nanoparticles for curcumin(CUR-HMSN@lip)was constructed.Its formulation and process parameters were optimized,and its pharmacokinetic behavior in rats was investigated.The obtained CUR-HMSN@lip was characterized by TEM,PXRD,ζ potential,and thermogravimetric analyses,and the results indicated that the curcumin-loaded hollow mesoporous silica nanoparticles(CUR-HMSN)were successfully encapsulated by phospholipids.After orally administered of CUR-HMSN@lip to rats,the pharmacokinetic parameters of curcumin were determined and calculated.The results were as follows:tmax was(1.83±0.41)h,AUClast was(570.82±48.07)h·ng·mL-1,and MRTlast was(5.68±1.21)h.Compared with the CUR-HMSN treatment group,the plasma concentration-time curve of the CUR-HMSN@lip treatment group did not show a double peak phenomenon.The relative bioavailability of CUR-HMSN@lip was 203.8％.It was concluded that the CUR-HMSN@lip delivery system increased the bioavailability of curcumin and improved the burst release of CUR-HMSN.
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