The oral delivery of peptide and protein drugs has received widespread attention in recent years,and how to overcome gastrointestinal physiological barriers and improve bioavailability is a key issue in their clinical applications.Mesoporous silica is an artificially synthesized nanoscale inorganic porous material.Due to the unique properties,such as controllable particle size,pore size,morphology,and surface chemistry,mesoporous silica has the potential to serve as an oral delivery carrier for peptide and protein drugs.This article reviews the main barriers that hinder the oral absorption of peptides and protein drugs,the characteristics,synthesis,surface modification methods,and some recent advances of mesoporous silica,hoping to provide new ideas for the application of mesoporous silica to oral delivery of peptide and protein drugs.
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