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中药复杂溶液中纳滤技术的应用特点及挑战

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纳滤技术的无热效应特点使其能够应用于精制、分离中药中的热敏性成分.然而,随着分离环境由水向有机溶液的过渡,纳滤分离层的物理化学性质发生变化,导致适用于水溶液环境的分离模型难以指导有机溶液的有序化分离.可基于电荷效应、溶解-扩散效应、孔径筛分效应,探索纳滤分离的特征,并结合中药成分的存在状态和制剂生产规律,探索溶液环境对纳滤分离效应的调节规律.该文围绕中药复杂溶液环境中纳滤分离技术在中药制药领域的应用特点以及带来的挑战展开分析,综述了复杂溶液环境下中药成分的纳滤分离机制,为提升纳滤技术的适用性提供了参考依据.
Application Features and Challenges of Nanofiltration Technology in Complex Solution of Traditional Chinese Medicines
Nanofiltration,as a technology without thermal effect is suitable for the purification and separation of heat-sensitive components of traditional Chinese medicines(TCM).However with the transition of separation environment from water to organic solution,the physical and chemical properties of nanofiltration separation layer change,which makes it difficult for the separation model suitable for aqueous solution environment to guide the orderly separation of organic solution.Based on the charge effect,dissolution-diffusion effect and pore size screening effect,combined with the properties and production rules of TCM components,the regulation rules of complex solution environment can be explored.In this paper,the application features and challenges of nanofiltration separation technology in the field of TCM are analyzed around the complex solution environment.The nanofiltration separation mechanism in complex solution environment is reviewed,which provide a reference for improving the applicability of nanofiltration technology.

nanofiltrationcomplex solutionChinese medicine preparationseparation mechanismapplication featureresearch progress

章莲、徐扬阳、李存玉、支兴蕾、彭国平

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南京中医药大学药学院,江苏南京 210023

江苏省中药资源产业化过程协同创新中心,江苏南京 210023

中药制药过程控制与智能制造技术全国重点实验室,江苏连云港 222047

纳滤 复杂溶液 中药制剂 分离机制 应用特点 研究进展

国家自然科学基金项目国家自然科学基金项目江苏省自然科学基金项目

8227410682074006BK20211303

2024

中国医药工业杂志
上海医药工业研究院,中国化学制药工业协会

中国医药工业杂志

CSTPCD
影响因子:0.487
ISSN:1001-8255
年,卷(期):2024.55(7)