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对孔下料器下料过程中破片问题的研究与解决方案

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文章分析了素片在铝塑包装机对孔下料器(以下简称下料器)中的受力情况,通过计算和试验,解决下料过程中的破片问题.以下料过程中片剂的破片率和空泡率为评价指标,在单因素试验的基础上,利用Minitab 15.0软件对下料器中振动盘下降高度、振动频率、导向槽弧度的设置参数进行优化,并对所得拟合模型进行分析.力学分析结果显示,素片在下料器振动盘、导向槽以及下料轨道中均有明显的受力情况.在本研究中,所得的优化结果如下:选择平均硬度为45 N的药片,设置振动板气源压力为0.16 MPa,振动板上药片堆积厚度为2.5 cm,振动频率为37.00 Hz,振动板下降高度为3.00 mm,加工振动板导向槽弧度为95.00°.在上述条件下,以1 min生产200板的速度连续运行6 h,下料过程的破片率可降低至0,空泡率也仅为1.44%.此外,增加素片硬度,可提高片剂自身的机械强度,从而改善素片破片情况.
Research and Solution of Tablet Fragmentation in the Feeding Process of the Hole Feeding Device
In this paper,the stress of tablets in the hole feeding device of aluminum plastic packaging machine(hereinafter referred to as the feeding device)was analyzed,and solutions to the problem of tablet fragmentation in the feeding process were proposed through calculation and experimentation.The fragmentation rate and cavitation rate of the tablets during the feeding process were taken as the evaluation indexes.Based on the single factor test,Minitab 15.0 software was used to optimize the setting parameters of falling height,vibration frequency and guide groove radian of the vibrating disk in the feeding device,and the fitting models were analyzed.The mechanical analysis results showed that the tablets were obviously stressed in the vibrating plate,guide groove and blanking track of the feeding device.In this study,the optimal conditions were as follows:selecting the tablets with an average hardness of 45 N as the models,the gas pressure of the vibrating plate was 0.16 MPa,the accumulation thickness of the tablets on the vibrating plate was 2.5 cm,the vibration frequency was 37.00 Hz,the falling height of the vibrating plate was 3.00 mm,and the radian of the guide groove of the vibrating plate was 95.00°.A continuous production was conducted under above conditions and at the speed of 200 plates per 1 min for 6 h,the fragmentation rate in the feeding process could be reduced to 0,and the cavitation rate was only 1.44%.In addition,increasing the hardness of the tablet can improve its own mechanical strength,thereby improving the problem of tablet fragmentation.

aluminum plastic packagingfeeding devicetablet fragmentationsolution

唐顺、徐洪辉、王云蔚、袁晓凡、徐秀卉

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杭州康恩贝制药有限公司,浙江杭州 310052

铝塑包装 下料器 破片 解决方案

2024

中国医药工业杂志
上海医药工业研究院,中国化学制药工业协会

中国医药工业杂志

CSTPCD
影响因子:0.487
ISSN:1001-8255
年,卷(期):2024.55(7)