Using fluorene(2)as the starting material,it was chlorinated by trichloroisocyanuric acid to obtain 2,7-dichlorofluorene(3),which was acylated with chloroacetyl chloride to produce 2,7-dichlorofluorene-4-chloroethyl ketone(4).Then,α-(di-n-butylaminomethyl)-2,7-dichloro-4-fluorenylmethanol(5)was obtained via reduction,cyclization and amination by one-pot method.Finally,5 was condensed with p-chlorobenzaldehyde to obtain benfluorenol(1),with an overall yield of 36％and a purity of 99.4％.The improved process used trichloroisocyanuric acid as the chlorinating agent,which improved the selectivity and safety of the reaction.The reduction,cyclization and amination were completed by one-pot method,which reduced the reaction temperature,shortened the reaction cycle,improved production efficiency,and increased the yield from 60％to 80％.The improved process was simple to operate,low in production cost and suitable for industrial production.
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