Four potential related substances were synthesized,namely 2-[(7R,11R)-2,3-dihydroxy-3,7,11,15-tetramethylhexadecyl]-3-methylnaphthalene-1,4-dione(related substance A),1 α-methyl-7α-[(7R,11 R,E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1 α,7α-dihydronaphtho[2,3-b]oxirene-2,7-dione(related substance B),2-[(7R,11 R,E)-3-hydroxy-3,7,11,15-tetramethylhexadec-1-en-1-yl]-3-methylnaphthalene-1,4-dione(related substance C)and 2,5-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-benzo[h]chromen-6-ol(related substance D).Their structures were confirmed by 1H NMR and MS,which provided a reference for the quality control of vitamin K1.
vitamin K1related substancesynthesisquality control
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