An improved synthetic process of fludarabine phosphate(1)was developed.Commercially available fludarabine was subjected to a nucleophilic substitution with triethyl phosphate.Subsequently,the target compound 1 was obtained through hydrolysis of triethyl phosphate on exposure to phosphorus oxychloride condition with an overall yield of 81％and a purity of 99.91％.The optimized process bearing mild reaction conditions,simple operation and stable process had been tested by process verification,and was suitable for industrial production.
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