首页|LC-MS/MS法测定大鼠呼吸道中的硫酸沙丁胺醇及其肺组织分布

LC-MS/MS法测定大鼠呼吸道中的硫酸沙丁胺醇及其肺组织分布

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建立了 LC-MS/MS法测定大鼠气管支气管、肺组织中的硫酸沙丁胺醇.结果显示,硫酸沙丁胺醇在大鼠气管支气管、肺中的线性范围分别为10.41~10410、5.205~5 205 ng/g.不同组织样品的日内与日间RSD均小于15%.大鼠吸入给药后,硫酸沙丁胺醇在大鼠气管支气管及肺内呈现相似的动态变化过程,给药后即可达最大浓度,然后快速消除.吸入用硫酸沙丁胺醇溶液在靶部位气管支气管中的分布较多,为后续临床合理用药提供了参考依据.
Determination of Salbutamol Sulfate in Rat Respiratory Tract by LC-MS/MS and Its Lung Tissue Distribution
The LC-MS/MS method was established to determine salbutamol sulfate in rat tracheobronchial and lung tissues.The results showed that the linear ranges in tracheobronchial and lung tissues were 10.41-10 410 and 5.205-5 205 ng/g,respectively.The intra-and inter-day RSDs of the samples from different tissues were less than 15%.After inhalation administration,salbutamol sulfate showed similar dynamic changes in the tracheobronchial and lung tissues of rats,and reached maximum concentration immediately after administration,followed by rapid elimination.The inhalation of salbutamol sulfate solution was widely distributed in the tracheal and bronchus of the target site,which provided a reference basis for the clinical use.

salbutamol sulfateatomization inhalationLC-MS/MStracheal and bronchuslung tissue

左亚茹、杨娴、侯海婷、赵方红、马晓阳、孙立杰

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石家庄四药有限公司研发中心,河北石家庄 050035

化学药品无菌制剂产业技术研究院,河北石家庄 050035

河北省大容量注射剂工程技术研究中心,河北石家庄 050035

石家庄四药有限公司博士后科研工作站,河北石家庄 050035

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硫酸沙丁胺醇 雾化吸入 LC-MS/MS 气管支气管 肺组织

河北省创新能力提升计划项目河北省高层次人才资助项目

225A2704DB2022003038

2024

中国医药工业杂志
上海医药工业研究院,中国化学制药工业协会

中国医药工业杂志

CSTPCD
影响因子:0.487
ISSN:1001-8255
年,卷(期):2024.55(8)