Research Progress of Controllable and Responsive Nitric Oxide Nanodelivery Systems in Tumor Therapy
As an endogenous messenger molecule,nitric oxide has multiple effects in tumor treatment.It can not only induce tumor cell apoptosis but also achieve outstanding synergy with other treatment methods.To improve its therapeutic efficiency,researchers have designed and prepared various types of nitric oxide nanodelivery systems and applied to tumor therapy research.Among them,the controllable responsive nitric oxide nanodelivery systems have received extensive attention for their excellent on-demand release ability and brilliant therapeutic effect.This article mainly reviews the controllable responsive nitric oxide nanodelivery systems based on different nanomaterials and discusses their applications in tumor therapy from endogenous-based and exogenous-based stimuli-responsiveness respectively,in order to provide a reference for the further development of nitric oxide nanodelivery systems.
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