This study prepared three impurities of alprazolam(1)namely impurities D,H,and J,which were recorded in the EP 10.0,but their synthetic routes had not been reported in the literature.Additionally,during the stability study of 1 bulk drug,a new impurity Q was discovered.Its chemical structure was determined as[5-chloro-2-[3-[[[(7-chloro-5-hydroxy-5-phenyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-1-yl)methyl]amino]methyl]-5-methyl-4H-1,2,4-triazol-4-yl]phenyl](phenyl)methanone through high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy.The successful preparation of these four impurities is of great significance for the quality research of 1 bulk drug and its formulations.
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