用于胶质母细胞瘤治疗的siRNA非病毒递送系统研究进展
Research Progress on Non-viral Delivery Systems of siRNA for Glioblastoma Treatment
江芷萱 1贾瑞沂 1丁源 1陆伟跃2
作者信息
- 1. 复旦大学药学院药剂学系,智能化递药教育部及全军 重点实验室(复旦大学),上海 201203
- 2. 复旦大学药学院药剂学系,智能化递药教育部及全军 重点实验室(复旦大学),上海 201203;上海泰禛生物技术有限公司研发部,上海 201314
- 折叠
摘要
胶质母细胞瘤(GBM)是恶性程度较高的脑部肿瘤,具有高致残率、高复发率的特点.GBM经常规治疗后易复发,且耐药患者预后情况不佳.小干扰RNA(siRNA)能通过沉默特定基因、下调蛋白表达而产生疗效,可作为常规治疗的补充,进一步抑制GBM的发展进程.文章阐述了 siRNA递送入脑的困境、siRNA治疗GBM的作用机制,并总结了 5种用于 GBM治疗的siRNA非病毒递送系统,以期为siRNA在GBM治疗中的应用研究提供参考.
Abstract
Glioblastoma(GBM)is a highly malignant brain tumor with high disability and recurrence rate.Conventional treatment for GBM is prone to recurrence,and the prognosis of drug-resistant patients is unfavorable.Small interfering RNA(siRNA)can generate therapeutic effects by silencing specific genes and down-regulating protein expression,and can serve as a supplement to conventional treatment by inhibiting the development process of GBM.This review elaborates on the difficulties of siRNA delivery into the brain and the mechanism of GBM treatment by siRNA.Additionally,it summarizes the application of five non-viral siRNA delivery systems for GBM treatment,in order to provide a reference for the application research of siRNA in GBM treatment.
关键词
胶质母细胞瘤/siRNA/脂质纳米粒/脂质体/聚合物纳米粒/胶束/外泌体/研究进展Key words
glioblastoma/siRNA/lipid nanoparticle/liposome/polymeric nanoparticle/micelle/exosome/research progress引用本文复制引用
出版年
2024
NETL
NSTL
万方数据