Research Progress on Non-viral Delivery Systems of siRNA for Glioblastoma Treatment
Glioblastoma(GBM)is a highly malignant brain tumor with high disability and recurrence rate.Conventional treatment for GBM is prone to recurrence,and the prognosis of drug-resistant patients is unfavorable.Small interfering RNA(siRNA)can generate therapeutic effects by silencing specific genes and down-regulating protein expression,and can serve as a supplement to conventional treatment by inhibiting the development process of GBM.This review elaborates on the difficulties of siRNA delivery into the brain and the mechanism of GBM treatment by siRNA.Additionally,it summarizes the application of five non-viral siRNA delivery systems for GBM treatment,in order to provide a reference for the application research of siRNA in GBM treatment.
NETL
NSTL
万方数据
