载药角膜接触镜的研究进展
Research Progress of Drug-eluting Contact Lenses
李妍 1陶涛 1赵雁1
作者信息
- 1. 中国医药工业研究总院医药先进制造国家工程研究中心,上海 201203
- 折叠
摘要
由于人眼存在各种生理和解剖屏障,导致滴眼液等传统局部眼用制剂的生物利用度不足5％.而载药角膜接触镜的生物利用度可高达50％,并具有释药和矫正视力的双重功能.文章综述了载药角膜接触镜的制备方法、灭菌及质量评价的研究进展,并重点分析了不同制备方法在角膜接触镜载药和释药等方面的优劣,阐述了载药角膜接触镜关键功能属性的评价方法,以期为推动载药角膜接触镜的临床应用提供参考.
Abstract
Due to various physiological and anatomical barriers in the human eye,the bioavailability of topical ophthalmic preparations,such as eye drops,is less than 5％.While the bioavailability of drug-eluting contact lenses can achieve 50％,and the products have the dual functions of drug release and visual correction.This paper reviews the research progress of preparation methods,sterilization and quality evaluation of drug-eluting contact lenses.The advantages and disadvantages of different preparation methods in drug loading and release,as well as the critical functional attributes of drug-eluting contact lenses are emphasized,hoping to provide some references for promoting the clinical application of medicated contact lenses.
关键词
载药角膜接触镜/载药方法/质量评价/药物释放/功能属性/灭菌/研究进展Key words
drug-eluting contact lens/drug loading method/quality evaluation/drug release/functional property/sterilization/research progress引用本文复制引用
出版年
2024
NETL
NSTL
万方数据