Application of Design of Experiment in Formulation Optimization of Self-microemulsifying Drug Delivery System
Self-microemulsifying drug delivery system(SMEDDS)is one of the effective approaches to improve the solubility and bioavailability of poorly soluble drugs.The formulation screening and optimization is the key steps in the development of SMEDDS products.Design of experiment(DoE)methods are employed to evaluate the main effects of independent variables and their interactions on response variables in formulations,therefore they are widely used in formulation optimization.This review summarizes the principles,advantages and disadvantages of several experimental design methods and their application in SMEDDS products development,focusing on the D-optimal mixtures design,in order to provide some references for the selection of SMEDDS formulation optimization methods.
self-microemulsifying drug delivery systemformulation optimizationdesign of experimentD-optimal mixture design
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