纳米药物递送系统在肺部吸入给药中的研究进展
Advances of Nano Drug Delivery Systems in Pulmonary Inhalation Administration
李广宝 1张潇 1杜林龙 1贝阮婷 1庞鑫1
作者信息
- 1. 河南中医药大学药学院,河南郑州 450046
- 折叠
摘要
肺部吸入给药因生物利用度高、患者依从性好等优点,在治疗肺部疾病乃至发挥全身治疗方面展现出较大的临床应用价值.然而,肺部特殊的生理构造使得药物的递送存在多重屏障.纳米药物递送系统因具有独特的优势,被广泛应用于肺部吸入给药.文章详细介绍了阻碍药物转运的肺部吸入给药屏障以及几种吸入型纳米药物递送系统,以期为肺部吸入制剂的临床研究提供参考.
Abstract
Due to its high bioavailability and good patient compliance,pulmonary inhalation administration has demonstrated significant clinical application value in the treatment of lung disorders and even plays a role in systemic therapy.However,there are numerous obstacles to drug delivery because of the unique physiological structures of the lungs.Nano drug delivery system has been widely used in pulmonary inhalation administration for its special benefits.This paper suminarizes the pulmonary drug delivery barriers and several inhalable nano drug delivery systems in detail,in order to provide reference for future clinical studies of pulmonary inhalation preparation.
关键词
肺部吸入给药/肺部吸入给药屏障/纳米药物递送系统/研究进展Key words
pulmonary inhalation administration/pulmonary drug delivery barrier/nano drug delivery system/research progress引用本文复制引用
基金项目
国家自然科学基金青年科学基金项目(82001955)
中华中医药学会青年人才托举工程项目(2022-QNRC2-A04)
河南省科技研发计划联合基金(优势学科培育类)项目(222301420063)
出版年
2024
NETL
NSTL
万方数据