New Process of Extraction and Refining of Sinomenine Hydrochloride
The acid water extraction method was designed,and a new refining process for the sinomenine extraction solution was developed.Experimental parameters for extraction and purification were determined by computational optimization,and experimental verification was performed.Chloroform was recycled for 10 times.The content of sinomenine hydrochloride in the prepared product was determined by HPLC.The experimental parameter ranges were set as follows:in the alkaline system(E1),the pH value ranged from 9 to 10.During the extraction process,the volume ratio of chloroform to E,was 1∶10.During the water-washing process,the volume ratio of organic phase(O1)to water was 1∶3.During the acid-water stripping process,the volume ratio of organic phase(O2)to water was 1∶8.In the aqueous phase(A1),the pH value ranged from 4 to 5.Under the same feed amount,after chloroform was reused for five times,the purity of prepared sinomenine hydrochloride maintained stable.This study developed a new process for the preparation of sinomenine hydrochloride,demonstrating the feasibility of recycling chloroform and obtaining high-purity sinomenine hydrochloride,which could reduce solid waste and production costs.
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