Research Progress of Atropine Ophthalmic Formulations for Myopia Prevention and Control
Low-concentration atropine eyedrops,an ophthalmic formulation for delaying myopia of adolescents,has been widely recognized due to its clinical therapeutic effects.However,the commercialized atropine sulfate eyedrops,ophthalmic aqueous solution,have many problems,such as eye irritation caused by low pH value of the aqueous solution,poor stability of the preparations and poor patient compliance.In this review,the formulations and preparation processes of atropine sulfate ophthalmic preparations currently under development and on the market are summarized,the characteristics,advantages and disadvantages of various technical approaches for improving stability and compliance of atropine sulfate ophthalmic products are analyzed,hoping to provide some references for the optimization of atropine ophthalmic formulations.
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