Research Progress on Antitumor Mechanisms and Nano-based Delivery Systems of Concomitant Use of Curcumin and Doxorubicin
Doxorubicin is one of the potent drugs in the clinic for the treatment of blood cancers and solid tumors.However,side effects and drug resistance of doxorubicin pose major obstacles to its application in antitumor therapy.Curcumin exhibits multiple pharmacological effects such as antitumor activity,antioxidation,and anti-inflammation.When combined with doxorubicin,curcumin can enhance efficacy,reduce toxicity,and reverse multidrug resistance.Nevertheless,due to the poor solubility,instability,and low bioavailability of curcumin,the application of this combination therapy is limited.Currently,the nano drug co-delivery system offers numerous advantages in antitumor therapy.A nano-based co-loading delivery system of curcumin and doxorubicin can improve drug solubility,enhance stability,achieve targeted drug aggregation,and realize sustained-and controlled-release at the tumor site.This review summarizes the antitumor mechanisms of the concomitant use of curcumin and doxorubicin and their novel nano-based drug delivery systems in recent years,providing ideas for further research on this combination therapy and the development and application of their nano-formulations.
curcumindoxorubicinantineoplasticsmultidrug resistancenano-based drug delivery systemresearch progress
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