Finerenone(1)was synthesized from diketene and 4-methoxybenzylamine as the starting materials,through the aminolysis,condensation,Hantzsch cyclization,ethylation,and chiral resolution steps.After optimizing the reaction conditions,the overall yield of this process was 11.4％with the purity of 99.7％.The usage of 4-methoxybenzyl group as the protection group was reported at the first time in this route,which was suitable for industrial production.
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