Objective To analyze the prognostic value and molecular function of actin filament-associated protein 1 Like 1(AFAP1L1)in gastric cancer(GC).Methods Based on a large amount of RNA sequencing data from the cancer genome atlas(TCGA),as well as single-cell RNA sequencing(scRNA-seq)data from gene expression omnibus(GEO),Kaplan-Meier survival analysis was used to validate the prognostic value of AFAP1L1,and enrichment analysis to explore the potential biological functions of AFAP1L1.In addition,this study determined the relationship between AFAP1L1 and anti-tumor drug sensitivity.The expression characteristics of AFAP1L1 at the single-cell level were analyzed.Results Overexpression of AFAP1L1 in GC patients was associated with poor prognosis and participated in the regulation of angiogenesis.In addition,AFAP1L1 was associated with the sensitivity of anti-tumor drugs such as dasatinib and foretinib.Single-cell RNA sequencing(scRNA seq)data analysis showed that AFAP1L1 was mainly expressed in endothelial cells in GC samples.Conclusion Based on the results of bioinformatics analysis,AFAP1L1 can serve as a prognostic biomarker for GC.
关键词
胃癌/生物标志物/肌动蛋白丝相关蛋白1/生物信息学/表达预后
Key words
Gastric cancer/Biomarker/Actin filament-associated protein 1/Bioinformatics/Expression and prognosis
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万方数据