摘要
糖尿病视网膜病变(DR)是糖尿病微血管病变的重要表现,是糖尿病的诸多并发症之一,可导致视力下降,是全球中老年人群的几大致盲原因之一,使发病人群生活质量严重下降.其发病机制与多种因素相关,如高血糖、高血脂、炎症反应和氧化应激等,但具体发病机制尚未完全清楚.目前DR的治疗效果有限,因此,寻找针对DR研制的药品成为当务之急.姜黄素具有包括抗凋亡自噬、抗炎、抗氧化、抗血管生成和抗肿瘤生成等多种生物活性.近年来,很多研究也证实姜黄素可以预防多种糖尿病并发症,包括糖尿病导致的视网膜病变.然而,目前没有确切姜黄素治疗DR的作用机制.本文结合国内外研究的最新进展,探讨姜黄素对DR保护作用的机制.
Abstract
Diabetic retinopathy(DR)is an important manifestation of diabetic microangiopathy,one of the many complications of diabetes,which can lead to decreased vision,and is one of the major causes of blindness in the world's middle-aged and aged people,causing a serious decline in the quality of life of the affected population.Its pathogenesis is related to various factors,such as hyperglycemia,hyperlipidemia,inflammatory response,and oxidative stress,but the specific pathogenesis is not yet fully understood.At present,the therapeutic effect of DR is limited,so finding drugs developed for DR has become an urgent task.Curcumin has various biological activities,including anti-apoptotic autophagy,anti-inflammatory,antioxidant,anti-angiogenic,and anti-tumor activities.In recent years,many studies have also confirmed that curcumin can prevent a variety of diabetes complications,including retinopathy caused by diabetes.However,there is currently no definitive mechanism of action of curcumin in the treatment of DR.This article combines the latest research progress at home and abroad to explore the mechanism of curcumin's protective effect on DR.
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