Correlation analysis of lung function,serum inflammatory factors,and PRAM score in children with asthma
Objective To analyze the correlation between lung function,serum inflammatory factors,and pediatric respiratory assessment measure(PRAM)score in children with asthma as the study subjects.Methods A total of 158 children with asthma who were treated in Hongqi Hospital Affiliated to Mudanjiang Medical University from July 2021 to December 2022 were selected as the study subjects.Based on the PRAM grading results,the PRAM scores,lung function,and inflammatory factor levels of children with different grades were compared,and the correlation between lung function,inflammatory factor levels,and PRAM scores of children with different degrees of illness were analyzed.Results The PRAM score of children with moderate asthma was higher than that of the children with mild asthma,the percentage of forced vital capacity(FVC％)and percentage of forced expiratory volume in one second(FEV1％)was lower than that of the children with mild asthma,and interleukin-6(IL-6)and interleukin-7(IL-7)were higher than those of the children with mild asthma,with statistically significant differences(P<0.05).The PRAM score of children with severe asthma was higher than that of children with mild asthma and moderate asthma,and the FVC％,FEV1％score was lower than that of children with mild asthma and moderate asthma.The levels of IL-6 and IL-7 were higher than those of children with mild asthma and moderate asthma,with statistically significant differences(P<0.05).Furthermore,a correlation analysis was conducted between the test results of lung function and inflammatory factors in the children and the PRAM score.The PRAM score showed a significant correlation with indicators such as FEV1％,FVC％,IL-6,and IL-7(P<0.05).Conclusion There is a significant correlation between lung function and serum inflammatory factors in children with asthma and PRAM score,which can provide a basis and reference for determining the severity of asthma in children.
万方数据
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