Association analysis between PM2.5 exposure during pregnancy and full-term low birth weight infants
Objective To explore the association between PM2.5 exposure at various stages of pregnancy and the risk of full-term low birth weight infants.Methods The hospitalization data of 118 783 critically ill pregnant women who gave birth at 22 monitoring points in Hebei Province from September 1,2015 to December 31,2017,and air quality monitoring data for each stage of pregnancy were collected.According to whether the full-term newborn was a low birth weight infant,the total population was divided into a full-term low birth weight infant group and a full-term non-low birth weight infant group.The PM2.5 exposure during pregnancy between the two groups was compared,and the impact on the disease of full-term low birth weight infants was analyzed using a logistic regression model.Results The PM2.5 exposure levels at all stages of pregnancy in the full-term low birth weight infant group were significantly higher than those in the full-term non-low birth weight infant group(P<0.05).Exposure to PM2.5 during pregnancy increases the risk of full-term low birth weight infants.Every increase of 10 μg/m3 in PM2.5 exposure concentrations during full pregnancy,early pregnancy,mid-pregnancy,and late pregnancy increased the risk of full-term low birth weight infants by 4.9％,1.6％,1.7％,and 1.5％,respectively.Older pregnancy,younger pregnancy,fewer prenatal examinations,first birth,multiple births(≥2 births),multiple pregnancies,female fetus,pregnant women suffering from hypertensive disorder complicating pregnancy,placenta praevia,placental abruption,and heart disease are all independent risk factors for full-term low birth weight infants(P<0.05).Conclusion Exposure to high concentrations of PM2.5 during pregnancy can significantly increase the risk of full-term low birth weight infants,and it is important to take precautions during pregnancy.
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