Objective To explore the differential diagnostic value of serum CA72-4 and bile CA72-4 in benign and malignant obstructive jaundice(MOJ).Methods From June 1,2020,to June 1,2022,a total of 67 patients for endoscopic retrograde cholangiopancreatography(ERCP)examination or treatment in Fuzhou No.1 Hospital Affiliated with Fujian Medical University due to obstructive jaundice were enrolled and divided into benign and malignant groups.Serum samples were extracted before surgery,and bile samples were extracted during ERCP for tumor marker CA72-4 detection.Results The tumor marker CA72-4 was significantly higher in bile than in serum,with statistically significant difference(P<0.05).The bile and serum CA72-4 levels in the malignant group were higher than those in the benign group,with statistically significant differences(P<0.05).According to the Receiver Operating Characteristic(ROC)curve,the optimal cutoff values for serum and bile CA72-4 in diagnosing MOJ are 1.84 U/ml and 7.10 U/ml,respectively.Serum CA72-4 has a sensitivity of 63.30％and a specificity of 86.50％for the diagnosis of MOJ,while the sensitivity and specificity of bile CA72-4 were 83.30％and 89.20％,respectively.There was no correlation in serum and bile CA72-4 and total bilirubin levels between the benign and malignant groups(P>0.05).Conclusion The detection of serum CA72-4 and bile CA72-4 can be used as a differential diagnosis method for benign and malignant obstructive jaundice,with bile CA72-4 having better diagnostic efficacy than serum CA72-4.
关键词
梗阻性黄疸/良恶性/胆汁/肿瘤标志物/CA72-4/内镜逆行性胰胆管造影术
Key words
Obstructive jaundice/Benign and malignant/Bile/Tumor markers/CA72-4/Endoscopic retrograde
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