Study on the effect of establishing enteral nutrition at different times on T-lymphocyte subsets in very low birth weight infants
Objective To explore the numerical changes in the immune function(T-lymphocyte subset)of establishing enteral nutrition in very low birth weight(VLBW)infants at different stages.Methods A total of 90 infants with VLBW who met the inclusion criteria and were admitted to the neonatal intensive care unit(NICU)of the Second Nanning People's Hospital from 2021 to 2023 were selected as the study subjects.According to the time of establishing enteral nutrition,they were divided into the test group(within 3 days after birth),the control group 1(3-7 days after birth),and the control group 2(7 days after birth),with 30 cases in each group.The T-lymphocyte subsets,incidence of infectious diseases,hospitalization time,and hospitalization expenses of the two groups were statistically analyzed.Results On the 20th day after birth,the proportions of CD3+,CD4+,and CD4+/CD8+in children in the test group were higher than those in children in the control group 1 and control group 2,with statistically significant differences(P<0.05).The incidence of infectious diseases in children in the test group was lower than that in children in control group 1 and control group 2,with statistically significant differences(P<0.05).The hospitalization time of the test group was shorter than that of the control group 1 and control group 2,and the hospitalization time of the control group 1 was shorter than that of the control group 2,with statistically significant differences(P<0.05).The hospitalization expenses of the test group were lower than those of the control group 1 and control group 2,with statistically significant differences(P<0.05).Conclusion The early establishment of enteral nutrition for very low birth weight infants can improve the cellular immune function of newborns,reduce the infection rate and degree of infectious diseases in very low birth weight infants,shorten the length of hospitalization time,and reduce hospitalization expenses,which provides a theoretical basis for the opinion that early establishment of enteral nutrition can improve neonatal cellular immunity.
Very low birth weight infantsEnteral nutritionT-lymphocyte subsetsInfectious diseasesHospitalization timeHospitalization expenses
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维普
