Study and analysis of T lymphocyte subsets in peripheral blood in acute exacerbation of bronchiectasis
Objective To explore the immune status of patients with acute exacerbation of bronchiectasis by detecting CD3+,CD4+and CD8+T lymphocytes and CD4+/CD8+,so as to further analyze the relationship between Pseudomonas aeruginosa infection and T lymphocytes.Methods A total of 141 patients with acute exacerbation of bronchiectasis who were admitted to the department of Respiratory and Critical Care Medicine,Hongqi Hospital affiliated to Mudanjiang Medical University from October 2022 to April 2023 were included in the bronchiectasis group.After admission,sputum culture and measurement of T lymphocyte subsets in peripheral blood were performed.A total of 32 healthy people during the same period were included in the control group,and were detected for lymphocyte subsets in peripheral blood.The bronchiectasis group was divided into the Pseudomonas aeruginosa group(PA group)and the non-Pseudomonas aeruginosa group(non-PA group)according to whether Pseudomonas aeruginosa was detected or not.The correlation between CD3+,CD4+,CD8+T lymphocytes and CD4+/CD8+was analyzed in all groups.Results The levels of CD3+,CD4+and CD8+T lymphocytes in the bronchiectasis group were lower than those in the control group,with statistically significant differences(P<0.05).The level of CD4+/CD8+in the bronchiectasis group was lower than that in the control group,with no statistically significant difference(P>0.05).The levels of CD3+,CD4+and CD8+T lymphocytes in the PA group were lower than those in the non-PA group,with statistically significant differences(P<0.05).The level of CD4+/CD8+in the PA group was lower than that in the non-PA group,with no statistically significant difference(P>0.05).Conclusion The levels of CD3+,CD4+and CD8+T lymphocytes in peripheral blood of patients with acute exacerbation of bronchiectasis decrease,especially in patients with Pseudomonas aeruginosa infection.It is speculated that CD4+and CD8+T lymphocytes play a certain role in acute exacerbation of bronchiectasis.
BronchiectasisT lymphocytesPseudomonas aeruginosaImmune state
万方数据
维普
