Connective tissue disease is a type of autoimmune disease caused by immune dysfunction,often involving multiple systems.Lung involvement is one of the most common complications of connective tissue disease,with interstitial lung disease being the most common.At present,relevant studies on immune mechanisms have confirmed the complexity of the pathogenesis of connective tissue disease-associated interstitial lung disease(CTD-ILD),and also provide new clinical diagnostic and treatment ideas.This article will summarize and discuss the main candidate biomarkers of interstitial lung disease related to connective tissue disease,such as GM-CSF,IL,S100A8/A9,CA153,MUC5B,etc.by reviewing the mechanisms,potential,limitations,and clinical applications in different CTD-ILD,which will help guide future clinical research and practice,reduce clinical missed diagnosis rates,conduct early treatment,and improve patient prognosis.
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