Research progress on the correlation between CYP2C19 genotype and drug metabolism
The cytochrome P450(CYP450)family is one of the most important drug oxidative metabolic enzymes in the human body,and cytochrome P450 2C19(CYP2C19)is an important member of the CYP450 family,participating in the oxidative metabolism of many drugs.The gene polymorphism of drug metabolic enzymes is considered to be the main reason for differences in drug response among individuals.The CYP2C19 gene polymorphism affects the metabolism of many drugs and is closely related to the clinical efficacy and safety issues of several commonly used prescription drugs.According to the CYP2C19 gene polymorphism,the population can be divided into four categories:slow metabolism type,intermediate metabolism type,normal metabolism type,and ultrafast metabolism type.The article mainly introduces the research progress on the correlation between CYP2C19 gene polymorphism and metabolic drugs,to provide a reference basis for clinical individualized and rational drug use.
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