The efficacy and safety of combining cardiotonic and diuretic therapy with Entresto in the treatment of heart failure after myocardial infarction
Objective To explore the clinical effect of combining cardiotonic and diuretic therapy with Entresto in the treatment of heart failure(HF)after myocardial infarction(MI).Methods A total of 68 patients with post-MI HF diagnosed clinically at East District Hospital in Ji'nan Innovation Zone from June to December 2022 were included.The patients were evenly divided into the control group and the observation group using a simple randomization method.The control group(34 cases)received cardiotonic and diuretic treatment,while the observation group(34 cases)received cardiotonic and diuretic treatment combined with Entresto.The clinical efficacy,cardiac function indicators,myocardial injury indicators,neuroendocrine factors,and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was 94.12％,higher than 76.47％of the control group,with statistically significant difference(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)and cardiac output(CO)in the observation group were higher than those in the control group,while the left ventricular end-systolic diameter(LVDs)and left ventricular end-diastolic diameter(LVDd)were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of cardiac troponin I(cTn-I),myoglobin(Myo),and creatine kinase isoenzyme(CK-MB)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of N-terminal pro-brain natriuretic peptide(NT pro-BNP),serum renin(RA),and angiotensin Ⅱ(Ang Ⅱ)in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).Compared to 8.82％in the control group,the total incidence of adverse reactions such as hypotension,gastrointestinal reactions,arrhythmia,and vascular edema in the observation group was 5.88％,without statistically significant difference(P>0.05).Conclusion The combination of cardiotonic and diuretic therapy with Entresto in the treatment of HF after MI has a significant overall effect in improving cardiac function indicators,myocardial injury indicators,and levels of neuroendocrine factors,which has fewer adverse reactions and is worthy of recommendation and application.
Myocardial infarctionHeart failureCardiotonic and diureticEntrestoClinical efficacyCardiac function
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