Analysis of influencing factors of physical activity levels in patients with stable chronic obstructive pulmonary disease
Objective To explore the relationship between physical activity levels,blood gas analysis,and lung function in patients with stable chronic obstructive pulmonary disease(COPD).Methods A total of 103 patients with chronic obstructive pulmonary disease from January 2021 to April 2022 in the pulmonary Department of the Third People's Hospital Affiliated to Fujian University of Chinese Medicine were retrospectively selected as the study objects.According to the level of physical activity of patients,they were divided into a high physical strength group,a moderate physical strength group and a low physical strength group.The general clinical data,blood gas analysis,and lung function of the three groups of patients were compared.Results There were 28 patients with high physical activity levels,59 patients with moderate physical activity levels,and 16 patients with low physical activity levels in these 103 patients with chronic obstructive pulmonary disease.After univariate analysis,the age,partial pressure of oxygen in arterial-blood(PaO2),carbon dioxide partial pressure(PaCO2),oxygen saturation(SaO2),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),FEV1/forced vital capacity(FVC),6-minute walking test(6MWD),nuclear factor-kappa B(NF-κB)and intercellular adhesion molecule-1(ICAM-1)of the three groups of patients were significantly different(P<0.05).PaO2,SaO2,FEV1,PEF,FEV1/FVC and 6MWD were positively correlated with physical activity levels,while PaCO2,NF-κB and ICAM-1 were negatively correlated with physical activity levels(P<0.05).Multivariate linear regression analysis showed that PaCO2,NF-κB and ICAM-1 of patients were independent risk factors for physical activity levels,while PaO2,SaO2,FEV1,PEF,FEV1/FVC and 6MWD were protective factors for physical activity levels(P<0.05).Conclusion High levels of PaO2,SaO2,FEV1,PEF,FEV1/FVC and 6MWD indicators are protective factors for physical activity levels,while high-level expressions of PaCO2,NF-κB and ICAM-1 are independent risk factors for physical activity levels,reflecting that the higher the level of physical activity,the better the recovery of lung function.In clinical practice,personalized rehabilitation activities can be developed based on the above indicators and factors of patients.
万方数据
维普
