首页|肝切除术联合淋巴结清扫治疗原发性肝癌预后及其影响因素分析

肝切除术联合淋巴结清扫治疗原发性肝癌预后及其影响因素分析

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目的 探讨肝切除术联合淋巴结清扫治疗原发性肝癌预后及其影响因素分析.方法 分析 2018 年 10月至2022年5月普宁市人民医院收治60例经病理证实为原发性肝癌患者,进行病理特征及治疗等指标分析,并分析这些指标对生存率、无瘤生存率的影响.结果 术后进行随访 1 年显示,本研究中所选取的患者半年和 1 年的无瘤生存率为 46.2%(24/52)、26.9%(14/52);单因素分析显示,发现方式、肿瘤直径、肿瘤TNM分期、根治分类、有无输血情况、复发与治疗、门静脉癌栓、病灶数量、肝硬化及淋巴结是否清扫均为影响原位性肝癌患者预后的因素(P<0.05);多因素分析显示,肿瘤直径、淋巴结清扫、根治分类、复发与治疗是术后生存率的影响因素(P<0.05),肝硬化类型、输血是无瘤生存率的影响因素(P<0.05).结论 复发后再手术切除、根治分类、淋巴结清扫及肿瘤直径为影响原发性肝癌患者的预后的独立危险因素,围手术期输血、肝硬化严重程度与无瘤生存率存在一定的关系.
Analysis of prognosis and influencing factors of primary liver cancer treated with hepatectomy combined with lymph node dissection
Objective To investigate the prognosis and influencing factors of hepatectomy combined with lymph node dissection for primary liver cancer.Methods 60 patients with pathologically confirmed primary liver cancer admitted to Puning People's Hospital from October 2018 to May 2022 were analyzed,and the pathological characteristics and treatment indexes were analyzed,and the effects of these indexes on the survival rate without cancer were analyzed.Results The 1-year follow-up showed that the 6-month and 1-year survival rates of the patients selected in this study were 46.2%(24/52)and 26.9%(14/52)respectively.Univariate analysis showed that factors such as discovery method,tumor diameter,TNM staging,radical classification,presence or absence of blood transfusion,recurrence and treatment,portal vein tumor thrombus,number of lesions,liver cirrhosis,and lymph node dissection were all factors affecting the prognosis of patients with primary liver cancer(P<0.05).Multivariate analysis showed that tumor diameter,lymph node dissection,radical classification,recurrence,and treatment were influencing factors for postoperative survival rate(P<0.05),while liver cirrhosis type and blood transfusion were influencing factors for tumor-free survival rate(P<0.05).Conclusion Surgical resection,radical classification,lymph node dissection,and tumor diameter are independent risk factors that affect the prognosis of patients with primary liver cancer after recurrence.There is a certain relationship between perioperative blood transfusion,severity of liver cirrhosis,and tumor-free survival rate.

HepatectomyLymph node dissectionPrimary liver cancerPrognosisInfluencing factor

张建、王锦祥、李晓辉

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广东省普宁市人民医院外二科,广东普宁 515300

肝切除术 淋巴结清扫 原发性肝癌 预后 影响因素

广东省揭阳市科技计划项目

ylxm081

2024

中国医药科学
海峡两岸医药卫生交流协会 二十一世纪联合创新(北京)医药科学研究院

中国医药科学

影响因子:1.083
ISSN:2095-0616
年,卷(期):2024.14(2)
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